منابع مشابه
Regulation of somatic firing dynamics by backpropagating dendritic spikes.
Pyramidal cells of the apteronotid ELL have been shown to display a characteristic mechanism of burst discharge, which has been shown to play an important role in sensory coding. This form of bursting depends on a reciprocal dendro-somatic interaction, in which discharge of a somatic spike causes a dendritic spike, which in turn contributes a dendro-somatic current flow to create a depolarizing...
متن کاملSubthreshold somatic voltage in neocortical pyramidal cells can control whether spikes propagate from the axonal plexus to axon terminals: a model study.
There is suggestive evidence that pyramidal cell axons in neocortex may be coupled by gap junctions into an "axonal plexus" capable of generating very fast oscillations (VFOs) with frequencies exceeding 80 Hz. It is not obvious, however, how a pyramidal cell in such a network could control its output when action potentials are free to propagate from the axons of other pyramidal cells into its o...
متن کاملLight Evokes Ca2+ Spikes in the Axon Terminal of a Retinal Bipolar Cell
Bipolar cells in the vertebrate retina have been characterized as nonspiking interneurons. Using patch-clamp recordings from goldfish retinal slices, we find, however, that the morphologically well-defined Mb1 bipolar cell is capable of generating spikes. Surprisingly, in dark-adapted retina, spikes were reliably evoked by light flashes and had a long (1-2 s) refractory period. In light-adapted...
متن کاملStructural inhomogeneities differentially modulate action currents and population spikes initiated in the axon or dendrites.
Action potentials (APs) in CA1 pyramidal cells propagate in different directions along the somatodendritic axis depending on the activation mode (synaptic or axonal). We studied how the geometrical inhomogeneities along the apical shaft, soma, and initial axon modulate the transmembrane current (I(m)) flow underlying APs, using model and experimental techniques. The computations obtained at the...
متن کاملAxons Amplify Somatic Incomplete Spikes into Uniform Amplitudes in Mouse Cortical Pyramidal Neurons
BACKGROUND Action potentials are the essential unit of neuronal encoding. Somatic sequential spikes in the central nervous system appear various in amplitudes. To be effective neuronal codes, these spikes should be propagated to axonal terminals where they activate the synapses and drive postsynaptic neurons. It remains unclear whether these effective neuronal codes are based on spike timing or...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2009
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2008.12.1236